Caliper In the News
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July 8, 2011
Discovery Through Innovation: Science In Action Featuring the 4th Annual Life Sciences AwardsCaliper Life Sciences to present and sponsor the 4th annual Life Sciences Award event. The event will be held at the U.S. Chamber of Commerce in conjunction with the Christopher Columbus Fellowship Foundation on Monday, July 11th. During the event, the Christopher Columbus Fellowship Foundation will provide approximately $70,000 in awards to a preeminent American scientist, three high school science teachers, as well as three high school students. The Foundation is currently in the process of receiving applicants for the Life Sciences Awards.
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May 19, 2010
The Collaborative Future: A Case StudyIn our February 2010 special report, “The Time Has Come for Automation in Bioprocessing,” one theme that made itself clear was the need for vendors, biopharmaceutical companies, and sometimes even regulators to work together toward the goal of better, faster, and cheaper product development through (among other things) automation technologies. Martin Rhiel of Novaris cell and process R&D told us, “It would be really nice to just buy it and implement it, but this doesn’t always work. . . . Nowadays, the FDA is working together with pharmaceutical companies in implementing new technologies.”
Source: BioProcess International
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May 15, 2010
Accelerating Small Molecule ResearchWhile the 21st century has witnessed great strides in the life science research tools industry, it has also witnessed a simultaneous decline in productivity in the pharmaceutical industry, to the extent that small molecule R&D, on average, is currently a loss-making exercise. The problem of declining return on investment (ROI) is exacerbated by generic erosion, increased scrutiny from the FDA on the issue of drug safety, price controls and pressure from pending healthcare reform legislation, and increased hurdles for safety and/or efficacy in the new era of comparative effectiveness (CE)...
Source: Genetic Engineering Biotechnology News (GEN)
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March 17, 2010
In Vivo Imaging Technologies in Drug ResearchIn vivo imaging technologies provide insight into all stages of the drug development process from target identification to the optimization of clinical trials. By looking at disease processes and monitoring therapeutic effects in the living animal, researchers are able to unravel the complex biological events in real time and repeatedly image the same animals in a longitudinal study, providing a high level of statistical significance while sacrificing fewer animals.
Source: Drug Discovery & Development (DDN)
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March 9, 2010
Guest Commentary: Efficient R&D process can position a drug candidate for commercial successSource: DDN
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February 15, 2010
Preparing for the Next Influenza PandemicSince the H1N1 strain of influenza emerged last spring, there has been a flurry of activity to find strategies to treat the strain more effectively, to make doses of existing therapeutics go further, and to develop new vaccines more quickly than possible with the traditional chicken-and-egg method still used to produce most of the world’s vaccines...
Source: Genetic Engineering & Biotechnology News
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February 2, 2010
Hopkinton Firm Makes Time’s Top Discoveries ListThe top 10 discoveries of 2009,according to Time Magazine, include identifying a possible cure for colorblindness, a comprehensive examination of the earliest human skeletal remains ever found and finding gallons of water on the moon. Add to that list Hopkinton-based Caliper Life Science’s contribution: a robot that could revolutionize the way scientists perform experiments.
Source: Worcester Business Journal Online
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January 13, 2010
Meeting a Dual NeedCaliper partners with Prestwick to offer custom chemistry and biology programs for drug discovery
Source: Drug Discovery News (DDN)
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December 21, 2009
Caliper Life Sciences recently entered into an agreement with SRU BiosystemsCaliper Life Sciences recently entered into an agreement with SRU Biosystems to use its label-free BIND technology to offer new functional assays as part of its discovery alliances and services. Under the agreement, Caliper will use SRU’s label-free BIND technology for high-throughput screening and profiling for cell-based and biochemical assays. Financial terms of the agreement were not released.
Source: DDN
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August 17, 2009
Measuring prions by bioluminescence imagingPrions are infectious proteins that cause fatal neurodegenerative diseases. Because astrocytic gliosis marked by the deposition of fibrils composed of GFAP is a prominent feature of prion disease, we asked whether GFAP might be used as a surrogate marker for prions. To interrogate this, we inoculated prions into transgenic (Tg) mice expressing luciferase (luc) under the GFAP gene(Gfap) promoter . . .
Source: PNAS
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August 1, 2009
A Spontaneous Acinar Cell Carcinoma Model for MonitoringWe have generated an EL1-luc/TAg transgenic mouse model that develops spontaneous and bioluminescent acinar cell carcinomas. We applied this model to noninvasively monitor tumor development and drug response. Experimental Design: EL1-luc/TAg transgenic mice of 11 weeks of age were treated with rapamycin (5 mg/kg, i.p.) or vehicle for 6 to 12 weeks. Tumor development was monitored through bioluminescence imaging and necropsy at the study end point . . .
Source: Clinical Cancer Research
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July 8, 2009
Transforming Diagnostics with MicrofluidicsLab-on-a-chip technology has helped transform diagnostics as a replacement for gel electrophoresis and also by enabling highthroughput, low-volume high-performance liquid chromatography (HPLC) enzymatic assays for drug discovery....
Source: MD&DI
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July 7, 2009
Systematic knockdownVICTORIA, Australia—The Peter MacCallum Cancer Centre (PMCC) is working with drug discovery and life sciences research tool provider Caliper Life Sciences, Inc. to automate oncology-related lab discovery experiments, speeding up its efforts to understand how to treat and prevent cancer through gene knockdown therapies.
Source: Drug Discovery News (DDN)
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June 5, 2009
In vivo molecular imaging: the inside jobIn a short period of time, in vivo molecular imaging systems have become indispensable research tools in many clinical and basic research laboratories. But developers are now pushing the technology further in the hopes of making a new generation of platforms with greater accuracy and sensitivity for a wider array of applications.
Source: Nature - Methods
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April 27, 2009
Imaging Through the PipelineSource: Drug Discovery & Development
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April 21, 2009
Hopkinton Firm Develops Puzzling Robot -
April 20, 2009
In Vivo ImagingSource: Biocompare
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April 10, 2009
Genomics WorkstationSource: Science
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April 2, 2009
Simplifying AutomationSource: Bioscience Technology
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April 1, 2009
Microfluidic Systems make the Impossible PossibleSource: BioPhotonics
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April 1, 2009
Simplifying Automation - The newest lab automation tools and technologies allow scientists to accomplish more with less resources.Source: Bioscience Technology
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January 1, 2009
High-throughput screening: designer screens"...But surprisingly, in biology,where today’s high-throughput screens often use multiple conditions, variables and reagents, the story has been quite different. “I am not sure why more people are not using DoE (Design of Experiments) in biology,” says Seth Cohen, director of Microfluidic Applications at Caliper Life Sciences in Hopkinton, Massachusetts, USA. At Caliper, Cohen and his team swear by the use of DoE format when it comes to finding optimal biochemical assay conditions, using it 100% of the time now to design reagents and optimize enzyme performance...."
Source: Nature Methods
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November 6, 2008
Life Science TechnologiesSource: Science Magazine
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November 3, 2008
Lighting up in vitro and in vivo workSource: Drug Discovery News
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November 1, 2008
What Lies Ahead?Source: Drug Discovery & Development
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October 30, 2008
Caliper Grabs $15.8M In Product Line SaleSource: Worcester Business Journal
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October 30, 2008
Caliper sells biz unit for $15.8M to SOTAXSource: Mass High Tech
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October 29, 2008
Caliper to Sell PDQ Product Line to Sotax for $15.8MSource: Genomeweb
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September 30, 2008
Small Animal Molecular Imaging SystemSource: Drug Discovery & Development
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August 1, 2008
Freedom of ExpressionSource: Drug Discovery & Development
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July 28, 2008
Caliper Bets Future on Tools That Light Up Genes Before Researchers’ Eyes -
July 25, 2008
Increased dependence on pharma on biologic therapies.Source: Drug Discovery Today
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July 1, 2008
Integrated imaging aids precision surgerySource: BioOptics World
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June 12, 2008
Sector Snap: Invitrogen deal lifts life sciencesSource: Associated Press
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June 2, 2008
Geared Up for GPCRs*Microfluidics
Source: Drug Discovery News
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May 12, 2008
Sample prep is vital to growing water testing usesSource: Mass High Tech
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May 2, 2008
TB Research Helped by Caliper Equipment*Imaging
Source: Worcester Business Journal
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May 1, 2008
It's Tox SeasonBy Catherine Shaffer
Source: Drug Discovery & Development
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May 1, 2008
May’s Innovations: Tumor Cell Lines*Imaging
Source: Bioscience Technology
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May 1, 2008
Tactics for Training Staff on New TechnologiesBy Mike May
*Liquid handlingSource: Drug Discovery & Development
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May 1, 2008
Turning RNA into IVDBy Mike May
Source: Bioscience Technology
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April 21, 2008
Cancer Cell Detection Through In Vivo Imaging*Imaging
Source: Drug Discovery & Development
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April 1, 2008
Run Robot Run: Advances in AutomationBy Gina Shaw
*Liquid handlingSource: Bioscience Technology
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February 1, 2008
Combination Therapies Fortify Oncology Fight: Safer and More Effective Anticancer Treatments Could Emerge from Rational CouplingsBy Mark Hickinson, Ph.D. and Nate Cosper, Ph.D
Source: Genetic Engineering & Biotechnology News
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February 1, 2008
Driving Discovery from Inside Out: In Vivo Imaging Revitalizes Research MethodologiesBy Kathy Liszewski,
*ImagingSource: Genetic Engineering & Biotechnology News
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February 1, 2008
Lights! Camera! Action!By James Netterwald
*ImagingSource: Drug Discovery & Development
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January 1, 2008
Repositioning Idle Drugs via Systematic Serendipity Systems-based Approaches for Boosting Stalled DrugsBy Gail Dutton
*ImagingSource: Genetic Engineering & Biotechnology News
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August 20, 2007
"Faster innovation cycles through microfluidics technology"Source: Next Generation Pharmaceutical
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December 15, 2006
In Vivo Imaging for Drug DiscoverySource: Biophotonics International
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September 1, 2006
Getting on the critical path: better evaluation tools for drug discovery and developmentSource: Drug Discovery
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September 1, 2006
The Development of Biomarkers to Bridge Preclinical and Clinical StudiesSept/Oct 2006
Source: Pharma DD
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July 31, 2006
Shedding New LightShedding New Light: Cathy Flynn interviews Peter Lassota, Divisional VP of Oncology and Kevin Hrusovksy, President & CEO about what Xenogen's "firefly" technology is doing for drug developement. Contact: investor.relations@caliperLS.com to obtain a copy of this article
Source: MetroWest Daily News
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July 14, 2006
UPenn Researchers Use Xenogen ImagingSource: Cell-Based Assay News
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July 5, 2006
Though M&A deals in H1 '06 flat with last year, size of recent pacts could trigger more activitySource: BioCommerce Week
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April 15, 2006
Drug Discovery Assay: Microfluidic Capillary Electrophoresis Real-time Kinetic Assays for Kinases, Phosphatases, and ProteasesContact: investor.relations@caliperls.com to obtain a copy of this article
Source: Genetic Engineering News
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March 14, 2006
Integration, Robotics, and AutomationSource: Bio-IT World
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January 13, 2006
Strategies for safeguarding your merger and acquisition plansSource: MASS High Tech
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January 1, 2006
Answers to Commonly Asked Automation QuestionsSource: Advance for Administrators of the Laboratory
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December 20, 2005
A new weapon against tuberculosis?Source: innovations.report.de
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October 15, 2005
Caliper's LabChip Systems Target DiscoverySource: Genetic Engineering
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October 1, 2005
Microfluidic AnalyzersSource: BioScience Technology
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September 1, 2005
Bucking the Trend - a profile of Kevin HrusovskySource: PharmaVoice
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August 28, 2005
Microfluidics: Semiconductor-industry sensibilities are shrinking the life science labSource: The Scientist
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August 1, 2005
"Go with the microflow"[no link]
Source: Nature Methods
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August 1, 2005
The Do's and Don'ts of Automated Screening[no link]
Source: Drug Discovery and Development
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July 1, 2005
Strategic experiments lead to faster innovationSummer 2005
Source: Drug Discovery and Development
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March 14, 2005
Bio-IT World's Top 50 Companies -
March 1, 2005
"A Real World Test Site for Developing Technologies Used in Drug Discovery"[Spring 2005]