Software Version: LabChip GX V2.1
P/N 126805 Rev 01
The LabChip GX software controls the
LabChip GX and LabChip GX II instruments. The LabChip GX software is also used
to analyze and compare data in the form of gels or graphs across different
wells from the same or different LabChip GX data files. The software can also
compare data with similar characteristics by applying filters. Results can be
exported to graphic files or .csv (comma separated
values) files. The software can be installed in Reviewer mode to be used only
for data analysis. The 21 CFR Part 11 option can be installed on the LabChip GX
computer to comply with 21 CFR Part 11 requirements. The 21 CFR Part 11 option
supports remote data backup to a database on a network server. Use the CDR
Server Utility software to set up the remote server.
Microsoft© Windows XP with Service Pack 2 or higher
Minimum
RAM: 1Gb (2Gb recommended)
Microsoft® Windows XP Service Pack 2 or higher, OR Microsoft® Windows Vista
Minimum
RAM: 1Gb (2Gb recommended)
Microsoft® Windows XP Service Pack 2 or
higher, OR Microsoft® Windows Vista
Available Hard Disk Space: 10 - 20Gb (depending on use)
Minimum
RAM: 1Gb (2Gb recommended)
To install the LabChip GX software on
Windows XP:
1. Close
all open programs.
2.
Insert the LabChip GX Installation CD into the CD-ROM drive.
3.
Follow the instructions in the setup wizard.
If the
installation does not automatically start:
1. From
the Start menu, select Run.
2.
Type d:\setup.exe (or type the
drive letter of the CD-ROM drive).
3. Click
the OK button.
4.
Follow the instructions in the InstallShield wizard.
To
install the LabChip GX software on Windows Vista (Reviewer Mode ONLY):
1. Close
all open programs.
2. In
Windows Explorer, right-click on setup.exe and select “Run as administrator.”
3. In
the Warning dialog, select the Allow option. The InstallShield
Wizard displays the list of prerequisites.
4. Click
the Install button to install the required prerequisites. The LabChip GX InstallShield Wizard opens.
5.
Follow the instructions in the InstallShield wizard.
To install or set up the remote CDR, you
must log onto the Remote Server computer as a Windows administrator.
For security purposes, files and folders on
the remote server pc should not be shared or accessible by regular users on the
network.
If Subversion V1.5 or higher is installed
on the remote server, a dialog prompts you to manually uninstall subversion.
Installation will not continue until Subversion is uninstalled. After manually
uninstalling Subversion, restart the installation.
To install the CDR Server Utility software
on Windows XP:
1. In
Windows Explorer, double-click on CDRServerUtilitySetup.exe.
2. Follow the instructions in the InstallShield
wizard.
3. If this is the first time the CDR Server Utility is
installed, you must restart the computer.
To
install the CDR
Server Utility software
on Windows Vista:
1. In
Windows Explorer, right-click on CDRServerUtilitySetup.exe and select “Run as
administrator.”
2. In
the Warning dialog, select the Allow option. The CDR Server Utility InstallShield Wizard opens.
3. Follow
the instructions in the InstallShield wizard.
4. If this is the first time the CDR Server Utility is
installed, you must restart the computer.
To start the CDR Server Utility software, right-click on the
desktop icon and select ‘Run as Administrator.’
Troubleshooting Remote CDR Server installation:
1. After creating the server, verify the windows service
‘Subversion’ is running.
2. The Remote and Local computers should be in the same
workgroup. If they are not in same workgroup, use the IP Address instead of the
computer name when specifying the remote CDR server on the LabChip GX computer.
3. After creating the server and folder, if the Get Folder
Details check box was selected, the server name, folder name, username, and
password are saved in a text file in “C:\Program Files\Caliper Life Sciences\CDRServer\ServerDetails”. This
information is required for backing up the local folder on the LabChip GX
computer to the remote CDR folder.
To
uninstall the LabChip GX software:
1. From
the Start menu, select Control Panel.
2.
Double click on Add or Remove Programs
in the Control Panel.
3.
Select LabChip GX from the list of
installed programs.
4.
Click on the Remove button to uninstall the LabChip GX software.
New Features:
·
Ladder and Sample Dilution Ratio
Parameters – The Ladder and Sample Dilution Ratio Parameters can now be edited
for Protein Assays only. In the Analysis tab on the Assay Analysis window, the
Dilution Ratio for Ladder and Sample can be changed. If the sample is diluted
in addition to the dilution specified for the assay protocol, multiply the
default sample dilution by any additional dilution factor. The quantization
analysis can then correctly account for the actual dilution. For example: If
the customer applies an additional 1:1 dilution of the sample, the new sample
dilution ratio should be 0.045 * 0.5 = 0.0225. After changing the sample
dilution ratio, the analysis will report the concentrations of species in the
original sample, before any dilutions were performed. The ladder dilutions
should not normally be changed.
·
High Size Filtering – Provides
ability to use a shorter filter for smaller size peaks at the beginning of the
well and a longer filter for larger size peaks at the end of the well. This
feature prevents “ringing” of smaller size peaks when using longer filter for
entire well.
·
Merge Peaks – Provides ability to
combine two adjacent peaks into a single peak by excluding one peak and
extending the baseline of the remaining peak to include the excluded peak.
·
Smear Analysis – Provides ability to
define a range of data between two specified sizes. Smears display in the Well
Table view. Smears are similar to peaks and have many of the same properties.
·
Titer – Ability to define a set of
wells containing a molecule of known concentration. The range of concentrations
provide a calibration curve from computing sample concentrations from the peak
area. The titer replaces the Ladder well as the calibration standard for the
area to concentration conversion.
·
Auto Export Contrast Lane – Auto
Export settings now include ability to select a specific gel lane to use to set
minimum and maximum contrast for all exported gels.
·
Filter AND Options – Two filter AND
options are now available: AND (Well) and AND(Peak). AND(Peak) replaces the AND
option available in previous versions. AND(Peak) finds any well that contains a
single peak that matches all selected filters. AND(Well) finds any well that
contains peaks that match the selected filters. The peaks that match do not
have to be the same peak.
·
Collection Undo Option – Provides
ability to undo changes to Viewer locations, Split locations, Viewer
properties, and Filter list. (Does not undo changes to or affect loaded plates,
Analysis settings, Peak overrides, or Manual well selections.)
·
Print Enhancements – Print the Electropherogram and peak table/well table of a single well
on the same page. Printing E-Gram + Peak Table or E-Gram + Well Table in
Portrait interleaves the peak Table/Well Table with the Electropherogram.
Reduce the height of the Electropherogram graph in
interleaved printing to 44% of the page height.
·
Service Access Level in CFR Mode –
Added Service Access Level in 21 CFR Part 11 mode. By default, Service access
level has permission to Run Assay and Perform Validation.
·
Audit Trail Search in CFR Mode –
Search options added for searching Audit Trail:
1.
Search most recent entries: by
default lists latest 2000 records
2.
Search by dates: lists records within the selected
period
3.
Search entire database: lists all
records from database
4. Can now search
using User Name, Filename, or Event Category.
·
Audit Trail Manage Columns –
Provides ability to select columns to view in Audit Trail list by selecting
check boxes in Manage Columns Window. Also provides ability to set display
order of columns. (Removed multiple views from Audit Trail Window. Now only
provide one view.)
Open Issues in
LabChip GX V2.1:
· An error may
occur if the application is idle for a long time. (LCF-2387)
·
Front panel buttons may not function
after terminating the software using CakTaskClean
(LCF-1828)
·
CaliperServiceHost error on
starting the GX software for the first time after upgrading. Workaround:
Restart the GX software. (LCF-3283)
·
Instrument mode support not
available in Windows Vista. (LCF-3292)
·
On the last injection of a plate,
the software counts down to zero for the length of the run, but the electropherogram continues to draw the trace for ~20
seconds. (LCF-3440)
·
Electorpherogram may display a
black screen if no wells are selected when using Windows Vista default theme.
(LCF-3443)
·
CalTaskClean closes any open
document or window that starts with "LabChipGX",
not just the LabChip GX software. (LCF-3418)
·
Installer might not clean up all
files. (LCF-3431)
·
Selected peak in peak table may not
be visible in overlay electropherogram if there are
other peaks near it. (LCF-3273)
·
"USB Key not found" error
may occur while starting the software if the USB cable is disconnected in
between a run and then connected. Workaround: Unplug the cable again, plug it
back in, wait a few seconds, and then restart the software. (LCF-3401)
Complete
documentation is available in the LabChip
GX.chm HTML Help file (accessible by selecting Helpŕ LabChip GX Help in the software) or in the LabChip GX
User Manual.pdf.
Copyright (c) 2008 - 2009, Caliper Life
Sciences. All rights reserved.
Contact Caliper Technical Support by phone, fax, or e- mail from
8AM to 5PM Eastern Standard Time.
Telephone: 1-877-LABCHIP
(1-877-522-2447), toll free
Fax: (508) 435-3439
E-mail: tech.support@caliperLS.com
Internet Address: http://www.caliperLS.com