Nuclear Receptors
Nuclear receptors are a class of proteins found within the interior of cells that are responsible for recognizing the presence of steroid hormones and other molecules. These receptors have the ability to directly bind to DNA and regulate the expression of genes. The regulation of gene expression by nuclear receptors occurs when a molecule which affects the receptor's behavior is present, binds to a nuclear receptor, and results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression.
A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis.
CDAS offers a comprehensive list of nuclear receptor assays as seen below.
| Cat# | Assay Type | Assay Class | Assay Name | $/Well (USD) |
|---|---|---|---|---|
| 100-1038 | Binding | Estrogen | Estrogen (bov) | $46.00 |
| 100-1039 | Binding | Estrogen | Estrogen (h) NR3A1 | $59.00 |
| 100-0912 | Binding | Farnesoid | Farnesoid X Receptor (h), Agonist | inquire |
| 100-0911 | Binding | Farnesoid | Farnesoid X Receptor (h), Antagonist | inquire |
| 100-0448 | Binding | Glucocorticoid | Glucocorticoid (h) | $59.00 |
| 100-0893 | Binding | Mineralocorticoid | Mineralocorticoid (rat) | $57.00 |
| 100-0914 | Binding | PPAR | Peroxisome Proliferator Activated Receptor, Gamma (h) | $59.00 |
| 100-0873 | Binding | PPAR | Peroxisome Proliferator Activator Alpha (h) | $59.00 |
| 100-0154 | Binding | Progesterone | Progesterone (bov) | $46.00 |
| 100-0155 | Binding | Progesterone | Progesterone (h) | $59.00 |
| 100-0923 | Binding | Retinoic Acid | RARa, Agonist (h) | $59.00 |
| 100-0907 | Binding | Retinoic Acid | RARa, Antagonist (h) | $59.00 |
| 100-0877 | Binding | Retinoic Acid | Retinoic Acid Receptor (h) Antagonist Binding | $59.00 |
| 100-0913 | Binding | Retinoic Acid | Retinoic Acid Receptor (rat) | $57.00 |
| 100-0922 | Binding | Testosterone (Androgen) | Constitutive Androstane Receptor (h) NR1I3 | $59.00 |
| 100-0901 | Binding | Testosterone (Androgen) | Constitutive Androstane Receptor, Antagonist (h) | $59.00 |
| 100-0167 | Binding | Testosterone (Androgen) | Testosterone Cytosolic (h) | $59.00 |
| 100-0168 | Binding | Testosterone (Androgen) | Testosterone Nuclear | $83.00 |