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Phosphodiesterases (PDE)

Phosphodiesterase enzymes are a unique family of enzymes and as such have recently been recognized as new target classes in drug discovery. They regulate the amplitude and duration of responses triggered by the second messengers, cAMP and cGMP. In doing so, they regulate a wide range of biological responses triggered by light, hormones, neurotransmitters and odorants.

PDEScreen™ from Caliper Discovery Alliances & Services (CDAS) represents all 11 of the known Phosphodiesterase classes and includes 17 of the 21 PDE genes identified. Using all human target assays optimized on the LabChip® platform, you will receive high-quality, cost-effective data with a rapid turnaround time (2 weeks or less).  The families of PDEs that are represented are listed below:

 PDE Family 

 Related disease area

 PDE1  Heart disease, Olfaction, CNS
 PDE2   Heart disease, Anti-angiogenesis, CNS
 PDE3  Obesity, Restenosis, Diabetes
 PDE4  Inflammation, Arthritis, Learning, Stroke, PD, Leukemia, CNS, Depression
 PDE5  ED, Pulmonary Hypertension, Migraine, CNS
 PDE6  CNS
 PDE7   CNS
 PDE8    Hyperthyroidism, Metabolic Bone Disease, CNS
 PDE9   CNS
 PDE10 Schizophrenia, Bipolar disorders, Addiction, CNS
 PDE11  Fertility


PDEScreen™ Services


     PDEScreen Profiling

        • Extensive panel of 20 human PDE assays
        • Rapid turnaround time in only two weeks or less

     PDEScreen IC50
        • Compound inhibitor potency determined in your selection of PDE assays

     PDEScreen Mechanism of Action (MoA)
        • Understand the manner in which your compounds interact with enzymatic targets 

     PDEScreen HTS
        • Customized screening projects to meet your clients’ expectations of throughput, process and workflow


 

PDEScreen Advantages

        • All Human Source Material
        • Broad PDE Coverage
        • Low Sample Usage
        • Mechanism of Action (MoA) Studies - Real-Time Kinetics
        • High Quality Data
        • Substrate Concentrations Close to Km



Complete List of PDE Assays


We offer an extensive panel of 20 human PDE assays:
Cat# Assay Type Assay Class Assay Name $/Well (USD)
200-1068 Enzyme PDE10A1 (h) PDE10A1 (h) $34.00
200-0943 Enzyme PDE10A2 (h) PDE10A2 (h) $34.00
200-0954 Enzyme PDE11A (h) PDE11A (h) $34.00
200-0966 Enzyme PDE1A1 (h) PDE1A1 (h) $34.00
200-1030 Enzyme PDE1B (h) PDE1B (h) $34.00
200-0967 Enzyme PDE2A (h) PDE2A1 (h) $34.00
200-0962 Enzyme PDE3A (h) PDE3A (h) $34.00
200-1031 Enzyme PDE3B (h) PDE3B (h) $34.00
200-0941 Enzyme PDE4A1A (h) PDE4A1A (h) $34.00
200-0963 Enzyme PDE4B1 (h) PDE4B1 (h) $34.00
200-1062 Enzyme PDE4C1 (h) PDE4C1 (h) $34.00
200-0957 Enzyme PDE4D2 (h) PDE4D2 (h) $34.00
200-0986 Enzyme PDE4D3 (h) PDE4D3 (h) $34.00
200-1064 Enzyme PDE4D7 (h) PDE4D7 (h) $34.00
200-0942 Enzyme PDE5A1 (h) PDE5A1 (h) $34.00
200-1035 Enzyme PDE6C (h) PDE6C (h) $57.00
200-0968 Enzyme PDE7A (h) PDE7A (h) $34.00
200-1066 Enzyme PDE7B (h) PDE7B (h) $34.00
200-0958 Enzyme PDE8A1 (h) PDE8A1 (h) $34.00
200-0955 Enzyme PDE9A2 (h) PDE9A2 (h) $34.00