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Phosphodiesterases (PDE)

Phosphodiesterase enzymes are a unique family of enzymes and as such have recently been recognized as new target classes in drug discovery. They regulate the amplitude and duration of responses triggered by the second messengers, cAMP and cGMP. In doing so, they regulate a wide range of biological responses triggered by light, hormones, neurotransmitters and odorants.

Caliper Discovery Alliances & Services’ (CDAS) PDEScreen™ represents all 11 of the PDE classes and 16 of the 21 PDE genes. Using all human targets coupled with Caliper’s proven LabChip platform, you will receive nothing but high quality data in 2 weeks or less.  The families of PDEs that are represented are listed below:

 PDE Family 

 Related disease area

 PDE1  Fertility, Inflammation, Olfaction
 PDE2   Heart disease, Anti-angiogenic
 PDE3  Obesity, restinosis, diabetes
 PDE4  Airway inflammation, arthritis, learning, stroke, PD, leukemia
 PDE5  ED, pulmonary hypertension, migraine
 PDE6  Retinopathies
 PDE7   Unknown
 PDE8    Hyperthyroidism, metabolic bone disease
 PDE9   Fertility
 PDE10  PD, OCD, addictions
 PDE11  Fertility


PDEScreen™ Services


     PDEScreen PROFILEing

        • Extensive panel of 16 human PDE assays
        • Rapid turn around time in only two weeks or less!

     PDEScreen IC50
        • Compound inhibitor potency determined in your selection of PDE assays

     PDEScreen Mechanism of Action (MoA)
        • Understand the manner in which your compounds interact with enzymatic targets 

     PDEScreen HTS
        • Customized screening projects to meet your clients’ expectations of throughput, process and workflow


 

PDEScreen Advantages

        • All Human Source Material
        • Broad PDE Coverage
        • Low Sample Usage
        • Availability of Real Time Kinetics - MoA
        • High Quality Data
        • Substrate Concentrations Close to Km



Complete List of PDE Assays

Cat# Assay Type Assay Class Assay Name $/Well (USD)
200-0943 Enzyme Phosphodiesterases PDE10A1 (h) $32.00
200-0954 Enzyme Phosphodiesterases PDE11A4 (h) $32.00
200-0966 Enzyme Phosphodiesterases PDE1A (h) $32.00
200-1030 Enzyme Phosphodiesterases PDE1B (h) $32.00
200-0967 Enzyme Phosphodiesterases PDE2A (h) $32.00
200-0962 Enzyme Phosphodiesterases PDE3A (h) $32.00
200-1031 Enzyme Phosphodiesterases PDE3B (h) $32.00
200-0941 Enzyme Phosphodiesterases PDE4A1A (h) $32.00
200-0963 Enzyme Phosphodiesterases PDE4B1 (h) $32.00
200-0957 Enzyme Phosphodiesterases PDE4D2 (h) $32.00
200-0986 Enzyme Phosphodiesterases PDE4D3 (h) $32.00
200-0942 Enzyme Phosphodiesterases PDE5A1 (h) $32.00
200-1035 Enzyme Phosphodiesterases PDE6C (h) $57.00
200-0968 Enzyme Phosphodiesterases PDE7A1 (h) $32.00
200-0958 Enzyme Phosphodiesterases PDE8A1 (h) $32.00
200-0955 Enzyme Phosphodiesterases PDE9A2 (h) $32.00