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Comprehensive or Therapeutic Area-Focused Phenotyping


Comprehensive or Therapeutic Area-Focused PhenotypingHaving trouble identifying phenotypic differences between your genetically modified animals and their wildtype littermate controls?  Phenotypic characterization of genetically-modified animals is an important step and often a bottleneck in target identification, target validation and proof-of-concept studies.  The industrialized approach to comprehensive phenotyping adapated at CDAS provides a combination of speed and in-depth characterization of in vivo functions.
 
CDAS has formed a multidisciplinary team of physiologists, behavioralists, immunologists, pharmacologists, biochemists and molecular biologists who work collaboratively to assess the effect of a genetic modification in the whole animal.  The program is designed to minimize the overall number of mice required for phenotyping without sacrificing the number of animals challenged in any given assay or more importantly, the quality of data generated.  This is achieved by running the animals sequentially through multiple bioassays.  The company has experimentally proven that serial combinations of bioassays used in its proprietary phenotyping platform do not affect the results of subsequent bioassays.

Our proprietary program, which utilizes Serial Phenotyping Compression Technology, or 'SPCT', allows both economic and time savings. Our customers are offered access to a customized set of bioassays, including many challenge assays, presently drawn from a battery of more than 85 pharmacologically-validated phenotypic assays, where up to 500 parameters/data points may be measured. These assays are designed to identify relevant phenotypes in most therapeutic areas, and the resulting data defines the physiological and behavioral profiling of their targets.  It’s time to add multi-parameter phenotypic assays and strategies to your target validation strategy, especially if it involves the phenotypic examination of genetically modified animals.

For more information please review the related downloads, email us directly at phenotyping@caliperls.com or complete and submit the product inquiry form and a CDAS representative will contact you. 

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