Discovery 2 X-MAN
Double Mutated Cancer Gene Panel
• Primary druggable mutant vs. normal human cancer genotypes
• 5+ double KI cell-lines
• Drug resistance/ drug combinations/ repositioning; biomarkers; patient-relevance
• X-MAN Express protein & mRNA lysates
| Cancer Gene | Parental Cell | Notes |
|
PI3Ka (H1047R) & EGFR (del E746-A750) |
Normal Breast Epithelium |
Double knock-in of two activated mutant oncogenes |
|
EGFR (del E746-A750) & BRAF (V600E) |
Normal Breast Epithelium |
Double knock-in of two activated mutant oncogenes |
|
K-Ras (G13D) & PI3Ka (H1047R) |
Normal Breast Epithelium |
Double knock-in of two activated mutant oncogenes |
| PI3Ka (H1047R) + B-Raf (V600E) | Normal Breast Epithelium | Double knock-in of two activated mutant oncogenes |
