General SEP II

The GenSEPII profile contains the assays used to screen a diverse set of 2,300 compounds and generate CDAS Side Effect Database - SED™  a complete database of drug/chemicals pharmacology profiles. SED™ is routinely being used to assist with prediction of chemicals adverse effects, off-target effects and drug pre-purposing/repositioning.

GenSEP II incorporates a broad array of well characterized and validated in vitro assays which are important mediators of drug side effects or drug actions. Assay categories include GPCRs, Voltage-Gated Ion Channels, Ligand-Gated Ion Channels, Neurotransmitter transporters, Nuclear Receptors and Selected Enzymes. CDAS quality assurance and control processes for assays development, improvements and screens guarantee exceptional data quality to our customers. A Short Assay Protocol (SAP) for each assay can be found online for complete information on assay format, components, pharmacology of reference drugs and target literature information.

Add a Metobolic assay panel of the most relevant CYP450 assays to GenSEP II.  Select among our CYP Basic (6 targets), CYP Regulatory (17 targets) or CYP Explorer (31 targets) panels.  

For more information on our GenSEP II, other profile panels or other assay services and programs, contact us at CDAS@caliperls.com.

Assay Code	Price/Compound	Format
A - nonGLP	$6776.00	1 concentration, duplicate
B - nonGLP	$9956.00	1 concentration, triplicate
C - nonGLP	$12998.00	2 concentrations, duplicate
D - nonGLP	$19083.00	3 concentrations, duplicate
A - GLP	$10164.00	1 concentration, duplicate
B - GLP	$14934.00	1 concentration, triplicate
C - GLP	$19497.00	2 concentrations, duplicate
D - GLP	$28624.00	3 concentrations, duplicate

Cat#	Assay Type	Assay Class	Assay Name
100-0002	Binding	Adenosine	A1
100-0003	Binding	Adenosine	A2A (h)
100-0001	Binding	Adenosine	Transporter AOT (h)
100-0005	Binding	Adrenergic	Alpha 1A
100-0006	Binding	Adrenergic	Alpha 1B
100-0007	Binding	Adrenergic	Alpha 2A (h)
100-0008	Binding	Adrenergic	Alpha 2B
100-0009	Binding	Adrenergic	Alpha 2C (h)
100-0010	Binding	Adrenergic	Beta 1 (h)
100-0011	Binding	Adrenergic	Beta 2 (h)
100-0084	Binding	Angiotensin II	AT1 (h)
100-0012	Binding	Bradykinin	B2
100-0013	Binding	Calcium	Type L (Dihydropyridine Site)
100-0014	Binding	Calcium	Type N
100-0016	Binding	Dopamine	D1 (h)
100-1006	Binding	Dopamine	D2s (h)
100-0018	Binding	Dopamine	D3
100-0019	Binding	Dopamine	D4.4 (h)
100-0015	Binding	Dopamine	Transporter, DAT
100-0085	Binding	Endothelin	ETA (h)
200-0083	Enzyme	Esterase	Acetylcholine
100-0023	Binding	GABA	Chloride TBOB Site
100-0021	Binding	GABA	GABA-A Agonist Site
100-0022	Binding	GABA	GABA-A BDZ Alpha-1 Site
100-0024	Binding	GABA-B	GABA-B
100-0026	Binding	Glutamate	AMPA Site
100-0027	Binding	Glutamate	Kainate Site
100-0029	Binding	Glutamate	NMDA Agonist Site
100-0032	Binding	Glutamate	NMDA Glycine Strychnine-insensitive
100-0028	Binding	Glutamate	NMDA MK801 Site
100-0031	Binding	Glutamate	NMDA PCP Site
100-0033	Binding	Glycine	Glycine Strychnine-sensitive Site
100-0034	Binding	Histamine	H1
100-0086	Binding	Histamine	H2
100-0035	Binding	Histamine	H3
200-0440	Enzyme	Kinase, Protein	PKA (h)
200-0334	Enzyme	Kinase, Protein	PKC-alpha (h)
100-0036	Binding	Leukotriene	LTB4 (BLT)
100-0037	Binding	Leukotriene	LTD4 (CysLT1)
100-0038	Binding	Muscarinic	M1 (h)
100-0039	Binding	Muscarinic	M2 (h)
100-0040	Binding	Muscarinic	M3 (h)
100-0041	Binding	Muscarinic	M4 (h)
100-0042	Binding	Muscarinic	M5 (h)
100-0044	Binding	Neurokinin	NK1
100-0045	Binding	Neuropeptide Y	NPY2 (h)
100-0046	Binding	Nicotinic	a-BnTx Insensitive Neuronal
100-0089	Binding	Nitric Oxide	NOS (neuronal-binding)
100-0048	Binding	Norepinephrine	Transporter NET
100-0049	Binding	Opioid	Delta (DOP,OP1) (h)
100-0051	Binding	Opioid	Mu (h)
200-0941	Enzyme	PDE4A1A (h)	PDE4A1A (h)
200-0942	Enzyme	PDE5A1 (h)	PDE5A1 (h)
100-0052	Binding	Potassium	ATP Sensitive (KATP)
100-0054	Binding	Potassium	Ca2+ Activated (VI)
100-0330	Binding	Potassium	hERG (I[Kr]) (h)
100-0057	Binding	Serotonin	5HT1A (h)
100-0058	Binding	Serotonin	5HT1D
100-0059	Binding	Serotonin	5HT2A
100-0060	Binding	Serotonin	5HT2C
100-0061	Binding	Serotonin	5HT3
100-0062	Binding	Serotonin	5HT4
100-0063	Binding	Serotonin	5HT5A (h)
100-0064	Binding	Serotonin	5HT6 (h)
100-0065	Binding	Serotonin	5HT7 (h)
100-0056	Binding	Serotonin	Transporter SERT
100-0066	Binding	Sigma	S1
100-0067	Binding	Sigma	S2
100-0069	Binding	Sodium	Site 2
100-0070	Binding	Thromboxane	TXA2 (h)