Light Producing Animal Models
Caliper light producing animal models can be used to model disease pathways, providing researchers with information on where a drug affects a particular pathway. Armed with this information, researchers will be able to better understand the mechanism of action of a drug, expanding the potential for discovering novel therapeutic approaches. Furthermore, compound testing in these same models provides immediate data concerning bioavailability of the compound to the target tissue. Light producing animal models expand the applications for in vivo real-time imaging to include toxicology testing for both the pharmaceutical and chemical manufacturing industries.
In addition to utility in drug development and toxicology, light producing animal models can be used to further validate novel gene targets discovered through genomics. Induction of the luciferase reporter in a light producing animal model in response to a disease condition or a drug treatment, may provide critical information about the role of that gene in a disease pathway.
This innovative approach provides Caliper with the "next generation" of highly predictive models that will expand the use of in vivo optical imaging across multiple therapeutic areas and functional applications in drug discovery and preclinical development.
