Gadd45ß-luc
Overview
Gadd45ß-luc BP (P/N 119286) Breeding Pair or Gadd4ß-luc (P/N 119308) Individual Animal
Light producing animal model (LPTA®) CD1-Tg(Gadd45ß-luc)-Xen, commonly called Gadd45ß-luc, carries a transgene containing a 10.7 kb murine Gadd45ß gene, human ß-globin intron 2, and modified firefly luciferase cDNA (Promega pGL-3). Basal expression of the reporter was observed in the whole body in male and female mice. | Model: | Inflammatory Model |
| Mouse Strain: | CD1-Tg(Gadd45ß-luc)-Xen |
| Common Name: | Gadd45ß-luc |
| Genotype: | Hemizygote (currently breeding to homozygosity) |
| Background Strain: | Crl: CD-1 (ICR)BR |
| Coat Color: | Albino |
Applications
The Gadd45ß-luc LPTA® animal model is useful in studying apoptosis, Gadd45ß gene regulation, MAP kinase- and NF-κ B-mediated signaling pathways, and the treatment of inflammatory diseases and cancer.