NFκB-luc [Oslo]
Overview
NFκB-luc [Oslo] (P/N 119335) Breeding Pair or NFκB-luc [Oslo] (P/N 119350) Individual Animal
Light producing animal model (LPTA®) DBA/1, BALB/C-Tg(NFκB-RE-luc [Oslo])-Xen, commonly called NFκB-RE-luc (Oslo), carries a transgene containing 3 NFkB responsive element (RE) sites from the Igκ light chain promoter and modified firefly luciferase cDNA (Promega pGL-3). Basal expression of the reporter was observed in lymph node (neck), thymus (thoracic region), and Peyer's patches (abdominal region). The reporter is inducible during inflammatory processes triggered by LPS and TNFκ. This LPTA® animal model is available from Charles River Laboratories.| Model: | Inflammatory Model |
| Mouse Strain: | DBA/1, BALB/C-Tg(NFκB-luc [Oslo])-Xen |
| Common Name: | NFκB-luc |
| Genotype: | Hemizygous |
| Background Strain: | DBA/1 or BALB/C (originated in C57BL/6J x CBA/J hybrid and subsequently backcrossed into these background strains) |
| Coat Color: | DBA/1: Dilute Brown; BALB/C: Albino |
Applications
The NFκB-luc (Oslo) LPTA® animal model is useful in studying sepsis, arthritis, inflammatory bowel disease, apoptosis, tumor development, NFκB gene regulation, and the treatment of inflammatory diseases and cancer.