Tnfα-luc
Overview
Tnfα-luc BP (P/N 119323) Breeding Pair or Tnfα-luc (P/N 119324) Individual Animal
Light producing animal model (LPTA®) BALB/C-Tg(Tnfα-luc)-Xen, commonly called Tnfα-luc, carries a transgene containing a 2.5 kb upstream region of the murine TNFa gene, the native intron of the TNF gene, and modified firefly luciferase cDNA (Promega pGL-3), and a 1 kb downstream region of the TNFα gene containing the TTATTTAT repeat, which is important for TNFα gene regulation. Basal expression of the reporter was higher in LPS-treated mice than control mice, and highest in kidney, lung, intestine, heart, and fat. The reporter is inducible by LPS. This LPTA® animal model is available from Xenogen Biosciences, Cranbury, New Jersey, USA.| Model: | Inflammatory Model |
| Mouse Strain: | BALB/C-Tnfα-luc-Xen |
| Common Name: | Tnfα-luc |
| Genotype: | Hemizygote |
| Background Strain: | BALB/C |
| Coat Color: | Albino |
Applications
The Tnfα-luc LPTA® animal model is useful in studying sepsis, arthritis, inflammatory bowel disease, apoptosis, TNFα gene regulation, and the treatment of TNFα-mediated inflammatory diseases.