Gfap-luc
Overview
Gfap-luc BP (P/N 119287) Breeding Pair or Gfap-luc (P/N 119309) Individual Animal
Light producing animal model (LPTA®) FVB/N-Tg(Gfap-luc)-Xen transgenic mouse line, commonly called Gfap-luc, utilizes a 12 kb fragment of the Glial fibrillary acidic protein (Gfap) promoter, 850 bp human β-globin intron 2, and modified firefly luciferase cDNA (Promega pGL-3). Basal expression of the reporter is observed primarily in brain. Basal expression of the reporter in non-treated male and female was observed in ear, paw, and tail, and does not change during treatment. The reporter is inducible following injury to the CNS. This LPTA® animal model is available from Xenogen Biosciences, Cranbury, New Jersey, USA.| Model: | Miscellaneous Disease Models |
| Mouse Strain: | FVB/N-Tg(Gfap-luc)-Xen |
| Common Name: | Gfap-luc |
| Genotype: | Hemizygote |
| Background Strain: | FVB/N and C57Bl/6 |
| Coat Color: | Albino |
Applications
The Gfap-luc LPTA® animal model is useful in studying changes in the health of nerve tissue, primarily the CNS, resulting in Gfap gene regulation. Changes, such as those caused by physical trauma, chemical treatment, and bacterial infections resulting in injury or changes in pressure within the cerebral spinal fluid are most likely to induce Gfap-luc expression.
