hVEGF-luc/PC3M Reporter Cell Line

Overview

Designation:  hVEGF-luc/PC3M Reporter

Tissue: Human:  carcinoma; prostate

Source of Parental Line:  MD Anderson Cancer Center, the University of Texas

Description:
This reporter cell line was created by cloning the hypoxia-inducible human vascular endothelial growth factor 1 (hVEGF1) promoter into a reporter plasmid expressing luciferase and stably transfected into a prostate cancer cell line, PC3M. This reporter cell line can be utilized to detect early events of angiogenesis such as the activation of the hVEGF promoter, in vivo. This model may be used to screen compounds that block hVEGF1 expression during the early phase of tumor growth.