p53 Acetylated Peptide

Caliper’s p53 Acetylated Peptide contains amino acids position 313-320 of the Human p53 protein with an acetylated lysine at position 320

p53 (also known as protein 53 or tumor protein 53), is a transcription factor which in humans is encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cycle and thus functions as a tumor suppressor that is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome," "the guardian angel gene," and the "master watchman," referring to its role in conserving stability by preventing genome mutation. Trancriptional coactivators, like p300 or PCAF, can acetylate the carboxy-terminal end of p53, exposing the DNA binding domain of p53, allowing it to activate or repress specific genes. Deacetylase enzymes, such as Sirt1 and Sirt7, can deacetylate p53, leading to an inhibition of apoptosis. 

p53 Acetylated Peptide has been validated using Caliper's LabChip mobility shift platform.