Imaging Reagents Publications

Kim, J., K. Urban, et al. (2010). "Non-invasive detection of a small number of bioluminescent cancer cells in vivo." PloS one 5(2): e9364.

Beck, B., H. Kim, et al. (2009). "Adoptively transferred ex vivo expanded γδ-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer." Breast Cancer Research and Treatment: 1-10.

Le Dévédec, S., W. Van Roosmalen, et al. (2009). "An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2−/− γc−/− mouse." Clinical and Experimental Metastasis 26(7): 673-684.

Lim, E., K. Modi, et al. (2009). " In vivo Bioluminescent Imaging of Mammary Tumors Using IVIS Spectrum." Journal of Visualized Experiments (26).

Ranganath, S., Y. Fu, et al. (2010). "The use of submicron/nanoscale PLGA implants to deliver paclitaxel with enhanced pharmacokinetics and therapeutic efficacy in intracranial glioblastoma in mice." Biomaterials.

Thobe, M., D. Gurusamy, et al. (2009). "The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells." Oncogene 29(2): 214-226.

Zhang, H., J. Man, et al. (2010). "Tumor-targeted delivery of biologically active TRAIL protein." Cancer Gene Therapy.

Sharma, P., R. Singh, et al. (2010). "CCR9-mediates PI3K/AKT dependent anti-apoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide." International Journal of Cancer

Kosaka, N., H. Iguchi, et al. (2010). "Secretory mechanisms and intercellular transfer of microRNAs in living cells." Journal of Biological Chemistry.

Takeshita, F., L. Patrawala, et al. (2009). "Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes." Molecular Therapy 18(1): 181-187.

Sakaguchi, M., K. Kataoka, et al. (2009). "Overexpression of REIC/Dkk-3 in Normal Fibroblasts Suppresses Tumor Growth via Induction of Interleukin-7." Journal of Biological Chemistry 284(21): 14236.

Priddle, H., A. Grabowska, et al. (2009). "Bioluminescence imaging of human embryonic stem cells transplanted in vivo in murine and chick models." Cloning and Stem Cells 11(2): 259-267.

Okuda, T., Y. Kawaguchi, et al. (2009). "Enhanced Gene Delivery and/or Efficacy by Functional Peptide and Protein." Current Topics in Medicinal Chemistry 9(12): 1098-1108.

Korotcov, A., L. Shan, et al. (2009). "A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for MRI Dynamic Contrast Enhancement Study."

Hickson, J. (2009). In vivo optical imaging: Preclinical applications and considerations. Urologic Oncology: Seminars and Original Investigations, Elsevier.

Blagbrough, I. and C. Zara (2009). "Animal models for target diseases in gene therapy—using DNA and siRNA delivery strategies." Pharmaceutical research 26(1): 1-18.

Singh, A., T. Massoud, et al. (2008). Molecular Imaging of Reporter Gene Expression in Prostate Cancer: An Overview. Seminars in nuclear medicine, Elsevier.

Hokaiwado, N., F. Takeshita, et al. (2008). "Glutathione S-transferase Pi mediates proliferation of androgen-independent prostate cancer cells." Carcinogenesis 29(6): 1134.

Kuo, C., O. Coquoz, et al. (2007). "Three-dimensional reconstruction of in vivo bioluminescent sources based on multispectral imaging." Journal of biomedical optics 12: 024007.

Giubellino, A., Y. Gao, et al. (2007). "Inhibition of tumor metastasis by a growth factor receptor bound protein 2 Src homology 2 domain-binding antagonist." Cancer research 67(13): 6012.

Figg, W., H. Li, et al. (2007). "Pre-clinical and clinical evaluation of estramustine, docetaxel and thalidomide combination in androgen-independent prostate cancer." BJU International-British Journal of Urology 99(5): 1047-1055.

Casarez, E., M. Dunlap-Brown, et al. (2007). "Radiosensitization and modulation of p44/42 mitogen-activated protein kinase by 2-Methoxyestradiol in prostate cancer models." Cancer research 67(17): 8316.

Bednar, B., G. Zhang, et al. (2007). "Optical molecular imaging in drug discovery and clinical development." Expert Opinion on Drug Discovery 2(1): 65-85.

Beckers, A., S. Organe, et al. (2007). "Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells." Cancer research 67(17): 8180.

Lyons, S., E. Lim, et al. (2006). "Noninvasive bioluminescence imaging of normal and spontaneously transformed prostate tissue in mice." Cancer research 66(9): 4701.

HANAI, K., F. TAKESHITA, et al. (2006). "Atelocollagen-mediated systemic DDS for nucleic acid medicines." Annals of the New York Academy of Sciences 1082 (Oligonucleotide Therapeutics: First Annual Meeting of the Oligonucleotide Therapeutics Society): 9-17.

Cheung, A., A. Brown, et al. (2006). "Vasculature and tumor burden changes in Bevacizumab-treated xenografts measured using longitudinal imaging of whole-body surface bioluminescence and ultrasound biomicroscopy." Proceedings of the American Association for Cancer Research 2006(1): 646.

Beckers, A., S. Organe, et al. (2006). "Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside." Molecular cancer therapeutics 5(9): 2211.

Takeshita, F., Y. Minakuchi, et al. (2005). "Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo." Proceedings of the National Academy of Sciences of the United States of America 102(34): 12177.

Nagahara, S., F. Takeshita, et al. (2005). "199. Efficient Inhibition of Bone Metastasis Via Systemic Delivery of siRNA Using Atelocollagen-Mediated Delivery System." Molecular Therapy 11: S78.

Jenkins, D., Y. Oei, et al. (2003). "Bioluminescent imaging (BLI) to improve and refine traditional murine models of tumor growth and metastasis." Clinical and Experimental Metastasis 20(8): 733-744.

Jenkins, D., S. Yu, et al. (2003). "In vivo monitoring of tumor relapse and metastasis using bioluminescent PC-3M-luc-C6 cells in murine models of human prostate cancer." Clinical and Experimental Metastasis 20(8): 745-756.

Troy, T., D. Stearns, et al. (2002). Development of a 3D optical imaging system for in vivo detection of bioluminescence. Biomedical Topical Meeting.

Edinger, M., Y. Cao, et al. (2002). "Advancing animal models of neoplasia through in vivo bioluminescence imaging." European Journal of Cancer 38(16): 2128-2136.

Rice, B., M. Cable, et al. (2001). "In vivo imaging of light-emitting probes." Journal of Biomedical Optics 6: 432.

Contag, C., D. Jenkins, et al. (1999). "Use of reporter genes for optical measurements of neoplastic disease in vivo." Neoplasia (New York, NY) 2(1-2): 41.

Holland, S., A. Pan, et al. (2010). "R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer." Cancer Research 70(4): 1544.

Hickson, J., S. Ackler, et al. (2010). "Noninvasive molecular imaging of apoptosis in vivo using a modified firefly luciferase substrate, Z-DEVD-aminoluciferin." Cell Death & Differentiation.

Fogal, V., A. Richardson, et al. (2010). "Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation." Molecular and Cellular Biology 30(6): 1303.

Qamri, Z., A. Preet, et al. (2009). "Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer." Molecular cancer therapeutics 8(11): 3117.

Palma, J., Y. Wang, et al. (2009). "ABT-888 Confers Broad In vivo Activity in Combination with Temozolomide in Diverse Tumors." Clinical Cancer Research 15(23): 7277.

Mulivor, A., D. Barbosa, et al. (2009). "RAP-011, a soluble activin receptor type IIA murine IgG-Fc fusion protein, is a novel bone anabolic agent that prevents bone loss and skeletal metastases in a mouse model of metastatic breast cancer." Bone 44: 221-222.

Mulivor, A., D. Barbosa, et al. (2009). "Pharmacological Inhibition of Signaling through the Activin Receptor Type IIa Prevents Primary Tumor Growth and Skeletal Metastases in Mouse Models of Breast Cancer." Cancer Research 69(24 Supplement): 5058.

Hu, G., R. Chong, et al. (2009). "MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer." Cancer cell 15(1): 9-20.

Abdelkarim, M., E. Guenin, et al. (2009). "New Symmetrically Esterified m-Bromobenzyl Non-Aminobisphosphonates Inhibited Breast Cancer Growth and Metastases." PLoS ONE 4(3).

Woods, N., H. Yamaguchi, et al. (2007). "Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis." Cancer research 67(22): 10744.

Jenkins, D., Y. Hornig, et al. (2005). "Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice." Breast Cancer Res 7(4): 444-454.

Zhang, H., D. Fagan, et al. (2010). "Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation." Oncogene.

Nguyen, L., W. Zhong, et al. (2010). "Quantitative Analysis of PD 0332991 in Xenograft Mouse Tumor Tissue by a 96 well Supported Liquid Extraction Format and Liquid Chromatography/Mass Spectrometry." Journal of Pharmaceutical and Biomedical Analysis.

Neal, R., R. Singh, et al. (2010)"Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode." Breast Cancer Research and Treatment: 1-7.

Stan, S., E. Hahm, et al. (2008). "Withaferin A causes FOXO3a-and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo." Cancer research 68(18): 7661.

Shan, L., S. Wang, et al. (2008). "BIOLUMINESCENT ANIMAL MODELS OF HUMAN BREAST CANCER FOR TUMOR BIOMASS EVALUATION AND METASTASIS DETECTION." Ethnicity & Disease 18: S2-65.

Shan, L., S. Wang, et al. (2007). "Dual probe with fluorescent and magnetic properties for imaging solid tumor xenografts." Molecular Imaging 6(2): 85-95.

Jenkins, D., Y. Hornig, et al. (2005). "Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice." Breast Cancer Res 7(4): 444-454.

Dernell, W. and C. S. U. F. COLLINS (2005). Evaluation of Interacavitary Chemotherapy Delivery for Treatment of Mammary Carcinoma.

Zhang, H., J. Man, et al. (2010). "Tumor-targeted delivery of biologically active TRAIL protein." Cancer Gene Therapy.

Luo, Z., T. Huang, et al. (2010). "Use of in vivo imaging system-bioluminescence imaging to inspect tumor dynamic morphology." Panminerva medica 52(1): 1.

Marttila-Ichihara, F., K. Auvinen, et al. (2009). "Vascular adhesion protein-1 enhances tumor growth by supporting recruitment of Gr-1+ CD11b+ myeloid cells into tumors." Cancer research 69(19): 7875.

Xing, Y., X. Lu, et al. (2008). "The effect of high intensity focused ultrasound treatment on metastases in a murine melanoma model." Biochemical and biophysical research communications 375(4): 645-650.

Smith, E. and E. Schuchman (2008). "Acid sphingomyelinase overexpression enhances the antineoplastic effects of irradiation in vitro and in vivo." Molecular Therapy 16(9): 1565-1571.

Marttila-Ichihara, F., R. Turja, et al. (2008). "Macrophage mannose receptor on lymphatics controls cell trafficking." Blood 112(1): 64.

Inglefield, J., C. Dumitru, et al. (2008). "TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type I IFN." Journal of Interferon & Cytokine Research 28(4): 253-263.

Maksimow, M., M. Miiluniemi, et al. (2006). "Antigen targeting to endosomal pathway in dendritic cell vaccination activates regulatory T cells and attenuates tumor immunity." Blood 108(4): 1298.

Minakuchi, Y., F. Takeshita, et al. (2004). "Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo." Nucleic Acids Research 32(13): e109.

Garbuzenko, O., M. Saad, et al. (2009). "Intratracheal versus intravenous liposomal delivery of siRNA, antisense oligonucleotides and anticancer drug." Pharmaceutical research 26(2): 382-394.

Jenkins, D., Y. Oei, et al. (2003). "Bioluminescent imaging (BLI) to improve and refine traditional murine models of tumor growth and metastasis." Clinical and Experimental Metastasis 20(8): 733-744.

Tai, C., S. Hsiung, et al. (2007). "Automatic microfluidic platform for cell separation and nucleus collection." Biomedical Microdevices 9(4): 533-543.

Shimomura, T., S. Hasako, et al. (2010). "MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel." Molecular cancer therapeutics 9(1): 157.

Cabral, H., N. Nishiyama, et al. (2007). "Optimization of (1, 2-diamino-cyclohexane) platinum (II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity." Journal of Controlled Release 121(3): 146-155.

Razavi, R. and L. Harrison (2010). "Thermal Sensitization Using Induced Oxidative Stress Decreases Tumor Growth in an In Vivo Model of Hyperthermic Intraperitoneal Perfusion." Annals of Surgical Oncology 17(1): 304-311.

Peter, C., J. Kielstein, et al. (2007). "A novel bioluminescent tumor model of human renal cancer cell lines: an in vitro and in vivo characterization." The Journal of urology 177(6): 2342-2346.

Jenkins, D., Y. Oei, et al. (2003). "Bioluminescent imaging (BLI) to improve and refine traditional murine models of tumor growth and metastasis." Clinical and Experimental Metastasis 20(8): 733-744.

Mitchell, D., E. Pobre, et al. (2010). "ALK1-Fc Inhibits Multiple Mediators of Angiogenesis and Suppresses Tumor Growth." Molecular Cancer Therapeutics 9(2): 379.

Jenkins, D., Y. Hornig, et al. (2004). "Luciferase-expressing MCF-7-luc-F5 human breast cancer cells used to monitor mammary fat pad tumor growth and metastasis in vivo in nude-beige mice." Proceedings of the American Association for Cancer Research 2004(1): 1179.

Cirstoiu-Hapca, A., F. Buchegger, et al. (2010). "Benefit of anti-HER2-coated paclitaxel-loaded immunonanoparticles in the treatment of disseminated ovarian cancer: Therapeutic efficacy and biodistribution in mice." Journal of Controlled Release.

Hickson, J., S. Ackler, et al. (2010). "Noninvasive molecular imaging of apoptosis in vivo using a modified firefly luciferase substrate, Z-DEVD-aminoluciferin." Cell Death & Differentiation.

Xiao, K., J. Luo, et al. (2009). "A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer." Biomaterials.

Hunter, J., T. Neben, et al. (2005). "Bioluminescent monitoring of ovarian carcinoma growth and spread in mouse xenograft tumor models." Proceedings of the American Association for Cancer Research 2005(1): 256.

Scatena, C., M. Hepner, et al. (2004). "Imaging of bioluminescent LNCaP-luc-M6 tumors: a new animal model for the study of metastatic human prostate cancer." The Prostate 59(3): 292-303.

Neben, T., A. Clermont, et al. (2005). "Luciferase expressing LoVo-6-luc-1 human colon cancer cells used to monitor tumor growth and metastasis in vivo in scid-bg mice." Proceedings of the American Association for Cancer Research 2005(1): 908.

Cheung, A., A. Brown, et al. (2006). "Vasculature and tumor burden changes in Bevacizumab-treated xenografts measured using longitudinal imaging of whole-body surface bioluminescence and ultrasound biomicroscopy." Proceedings of the American Association for Cancer Research 2006(1): 646.

Engelsman, A., G. van Dam, et al. (2010). "In Vivo Evaluation of Bacterial Infection Involving Morphologically Different Surgical Meshes." Annals of Surgery 251(1): 133.

Hardy, J., P. Chu, et al. (2009). "Foci of Listeria monocytogenes persist in the bone marrow." Disease Models & Mechanisms 2(1-2): 39.

Engelsman, A., B. Krom, et al. (2009). "Antimicrobial effects of an NO-releasing poly (ethylene vinylacetate) coating on soft-tissue implants in vitro and in a murine model." Acta Biomaterialia 5(6): 1905-1910.

Engelsman, A., H. van der Mei, et al. (2009). "Real time noninvasive monitoring of contaminating bacteria in a soft tissue implant infection model." J. Biomed. Mater. Res. B Appl. Biomater 88: 123-129.

Vuong, C., S. Kocianova, et al. (2008). "Development of Real Time In Vivo Imaging of Device Related Staphylococcus epidermidis Infection in Mice and Influence of Animal Immune Status on Susceptibility to Infection." The Journal of infectious diseases 198: 258-261.

Glomski, I., A. Piris-Gimenez, et al. (2007). "Primary involvement of pharynx and Peyer's patch in inhalational and intestinal anthrax." PLoS Pathog 3(6): e76.

Schwan, W., L. Lehmann, et al. (2006). "Transcriptional activation of the Staphylococcus aureus putP gene by low-proline-high osmotic conditions and during infection of murine and human tissues." Infection and immunity 74(1): 399.

Hardy, J., J. Margolis, et al. (2006). "Induced biliary excretion of Listeria monocytogenes." Infection and immunity 74(3): 1819.

Park, H., K. Francis, et al. (2003). "Membranous cells in nasal-associated lymphoid tissue: a portal of entry for the respiratory mucosal pathogen group A streptococcus." The Journal of Immunology 171(5): 2532.

Orihuela, C., G. Gao, et al. (2003). "Organ-specific models of Streptococcus pneumoniae disease." Scandinavian journal of infectious diseases 35(9): 647-652.

Francis, K., J. Yu, et al. (2001). "Visualizing pneumococcal infections in the lungs of live mice using bioluminescent Streptococcus pneumoniae transformed with a novel gram-positive lux transposon." Infection and immunity 69(5): 3350.

Xu, X., S. Miller, et al. (2010). "Bioluminescent imaging of Clavibacter michiganensis subsp. michiganensis infection of tomato seeds and plants." Applied and Environmental Microbiology.

Harms, J., M. Durward, et al. (2009). "Evaluation of recombinant invasive, non-pathogenic Eschericia coli as a vaccine vector against the intracellular pathogen, Brucella." Journal of immune based therapies and vaccines 7(1): 1.

Rambow-Larsen, A., G. Rajashekara, et al. (2008). "Putative quorum-sensing regulator BlxR of Brucella melitensis regulates virulence factors including the type IV secretion system and flagella." Journal of bacteriology 190(9): 3274.

Woelfle, M., Y. Xu, et al. (2007). "Circadian rhythms of superhelical status of DNA in cyanobacteria." Proceedings of the National Academy of Sciences 104(47): 18819.

Sjölinder, H. and A. Jonsson (2007). "Imaging of disease dynamics during meningococcal sepsis." PLoS ONE 2(2).

Nijnik, A., L. Madera, et al. (2010). “Synthetic Cationic Peptide IDR-1002 Provides Protection against Bacterial Infections through Chemokine Induction and Enhanced Leukocyte Recruitment.” The Journal of Immunology 184(5): 2539.

Li, D., K. Gromov, et al. (2010). “Effects of antiresorptive agents on osteomyelitis.” Annals of the New York Academy of Sciences 1192(Skeletal Biology and Medicine): 84-94.

Hart, E., K. Azzopardi, et al. (2010). “Efficacy of antimicrobial polymer coatings in an animal model of bacterial infection associated with foreign body implants.” Journal of Antimicrobial Chemotherapy 65(5): 974.

Gromov, K. (2010). “Osteoclastic bone resorption in chronic osteomyelitis.” Dan Med Bull 57: b4131.

Gillrie, M., L. Zbytnuik, et al. (2010). “Divergent roles of Toll-like receptor 2 in response to lipoteichoic Acid and Staphylococcus aureus in vivo.” European Journal of Immunology 9999(999A).

Engelsman, A., G. van Dam, et al. (2010). “In Vivo Evaluation of Bacterial Infection Involving Morphologically Different Surgical Meshes.” Annals of Surgery 251(1): 133.

Balibar, C., X. Shen, et al. (2010). “CwrA, a gene that specifically responds to cell wall damage in Staphylococcus aureus.” Microbiology.

Sjollema, J., P. Sharma, et al. (2009). “The potential for bio-optical imaging of biomaterial-associated infection in vivo.” Biomaterials.

Glowalla, E., B. Tosetti, et al. (2009). “Proteomics-based identification of anchorless cell wall proteins as vaccine candidates against Staphylococcus aureus.” Infection and Immunity 77(7): 2719.

Ghali, S., K. Bhatt, et al. (2009). “Treating Chronic Wound Infections with Genetically Modified Free Flaps.” Plastic and reconstructive surgery 123(4): 1157.

Fernández, I., H. Mei, et al. (2009). “In vitro and in vivo comparisons of staphylococcal biofilm formation on a cross-linked poly (ethylene glycol)-based polymer coating.” Acta Biomaterialia.

Engelsman, A., B. Krom, et al. (2009). “Antimicrobial effects of an NO-releasing poly (ethylene vinylacetate) coating on soft-tissue implants in vitro and in a murine model.” Acta Biomaterialia 5(6): 1905-1910.

Engelsman, A., H. van der Mei, et al. (2009). “Real time noninvasive monitoring of contaminating bacteria in a soft tissue implant infection model.” J. Biomed. Mater. Res. B Appl. Biomater 88: 123-129.

De Kwaadsteniet, M. (2009). “Characterization of nisin F and its role in the control of respiratory tract and skin infections."

Crane, D., K. Gromov, et al. (2009). “Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis.” Journal of Orthopaedic Research 27(8).

Streker, K., T. Schafer, et al. (2008). “In vitro and in vivo validation of ligA and tarI as essential targets in Staphylococcus aureus.” Antimicrobial agents and chemotherapy.

Nejadnik, M., A. Engelsman, et al. (2008). “Bacterial colonization of polymer brush-coated and pristine silicone rubber implanted in infected pockets in mice.” Journal of Antimicrobial Chemotherapy 62(6): 1323.

Lorenz, U., C. Hüttinger, et al. (2008). “The alternative sigma factor sigma B of Staphylococcus aureus modulates virulence in experimental central venous catheter-related infections.” Microbes and infection 10(3): 217-223.

Li, D., K. Gromov, et al. (2008). “A Quantitative Mouse Model of Implant-Associated Osteomyelitis and the Kinetics of Microbial Growth, Osteolysis and Humoral Immunity.” Journal of orthopaedic research: official publication of the Orthopaedic Research Society 26(1): 96.

Kadurugamuwa, J. and K. Francis (2008). “Bioluminescent imaging of bacterial biofilm infections in vivo.” METHODS IN MOLECULAR BIOLOGY-CLIFTON THEN TOTOWA- 431: 225.

Heit, B., S. Robbins, et al. (2008). “PTEN functions to 'prioritize' chemotactic cues and prevent'distraction'in migrating neutrophils.” Nature immunology 9(7): 743-752.

Ohlsen, K. and U. Lorenz (2007). “Novel targets for antibiotics in Staphylococcus aureus.” Future Microbiology 2(6): 655-666.

Mortin, L., T. Li, et al. (2007). “Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria.” Antimicrobial agents and chemotherapy 51(5): 1787.

Li, D. (2007). Development of a quantitative murine model of implant-associated osteomyelitis and its use to demonstrate the adverse effects of anti-resorptive drugs and efficacy of an immuno-dominant antigen vaccine on Staphylococcus aureus infection of bone. Dissertation Abstracts International. 69.

Baddour, R., F. Dadani, et al. (2007). “High-Frequency Ultrasound Assessment of Antimicrobial Photodynamic Therapy In Vitro.” Journal of Biological Physics 33(1): 61-66.

Bisland, S. and S. Burch (2006). “Photodynamic therapy of diseased bone.” Photodiagnosis and Photodynamic Therapy 3(3): 147-155.

Bisland, S., C. Chien, et al. (2006). “Pre-clinical in vitro and in vivo studies to examine the potential use of photodynamic therapy in the treatment of osteomyelitis.” Photochemical & Photobiological Sciences 5(1): 31-38.

Yu, J., J. Wu, et al. (2005). “Monitoring in vivo fitness of rifampicin-resistant Staphylococcus aureus mutants in a mouse biofilm infection model.” Journal of Antimicrobial Chemotherapy 55(4): 528.

Xiong, Y., J. Willard, et al. (2005). “Real-time in vivo bioluminescent imaging for evaluating the efficacy of antibiotics in a rat Staphylococcus aureus endocarditis model.” Antimicrobial agents and chemotherapy 49(1): 380.

Kadurugamuwa, J., L. Sin, et al. (2004). “Noninvasive optical imaging method to evaluate postantibiotic effects on biofilm infection in vivo.” Antimicrobial agents and chemotherapy 48(6): 2283.

Kadurugamuwa, J., L. Sin, et al. (2003). “Rapid direct method for monitoring antibiotics in a mouse model of bacterial biofilm infection.” Antimicrobial agents and chemotherapy 47(10): 3130.

Kadurugamuwa, J., L. Sin, et al. (2003). “Direct continuous method for monitoring biofilm infection in a mouse model.” Infection and immunity 71(2): 882.

Sottnik, J., L. U’Ren, et al. (2010). "Chronic bacterial osteomyelitis suppression of tumor growth requires innate immune responses." Cancer Immunology, Immunotherapy 59(3): 367-378.

Ketonis, C., S. Barr, et al. (2010). "Bacterial Colonization of Bone Allografts: Establishment and Effects of Antibiotics." Clinical Orthopaedics and Related Research®: 1-9.

De Kwaadsteniet, M., C. van Reenen, et al. (2009). "Evaluation of Nisin F in the Treatment of Subcutaneous Skin Infections, as Monitored by Using a Bioluminescent Strain of Staphylococcus aureus." Probiotics and Antimicrobial Proteins: 1-5.

Li, M., K. Rigby, et al. (2009). "Staphylococcus aureus mutant screen reveals interaction of the human antimicrobial peptide dermcidin with membrane phospholipids." Antimicrobial agents and chemotherapy 53(10): 4200.

Koskinen, K., S. Nevalainen, et al. (2007). "VAP-1-deficient mice display defects in mucosal immunity and antimicrobial responses: implications for antiadhesive applications." The Journal of Immunology 179(9): 6160.

Palmer, K., L. Aye, et al. (2007). "Nutritional cues control Pseudomonas aeruginosa multicellular behavior in cystic fibrosis sputum." Journal of bacteriology 189(22): 8079.

Burkatovskaya, M., A. Castano, et al. (2008). "Effect of chitosan acetate bandage on wound healing in infected and noninfected wounds in mice." Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society 16(3): 425

Burkatovskaya, M., G. Tegos, et al. (2006). "Use of chitosan bandage to prevent fatal infections developing from highly contaminated wounds in mice." Biomaterials 27(22): 4157-4164.

Moskwa, P., D. Lorentzen, et al. (2007). "A novel host defense system of airways is defective in cystic fibrosis." American journal of respiratory and critical care medicine 175(2): 174.

Kuklin, N., D. Clark, et al. (2006). "A novel Staphylococcus aureus vaccine: iron surface determinant B induces rapid antibody responses in rhesus macaques and specific increased survival in a murine S. aureus sepsis model." Infection and immunity 74(4): 2215.

Georgel, P., K. Crozat, et al. (2005). "A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria." Infection and immunity 73(8): 4512.

Hoebe, K., P. Georgel, et al. (2005). "CD36 is a sensor of diacylglycerides." Nature 433(7025): 523-527.

Kuklin, N., G. Pancari, et al. (2003). "Real-time monitoring of bacterial infection in vivo: development of bioluminescent staphylococcal foreign-body and deep-thigh-wound mouse infection models." Antimicrobial agents and chemotherapy 47(9): 2740.

Lambrechts, S., T. Demidova, et al. (2005). "Photodynamic therapy for Staphylococcus aureus infected burn wounds in mice." Photochemical & Photobiological Sciences 4(7): 503-509.

Shi, L., K. Takahashi, et al. (2004). "Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus." Journal of Experimental Medicine 199(10): 1379.

Del Pozo, J., M. Rouse, et al. (2009). "Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms." Antimicrobial agents and chemotherapy 53(1): 35.

Del Pozo, J., M. Rouse, et al. (2009). "The electricidal effect: Reduction of Staphylococcus and Pseudomonas biofilms by prolonged exposure to low-intensity electrical current." Antimicrobial agents and chemotherapy 53(1): 41.

Dai, T., G. Tegos, et al. (2010). "Photodynamic therapy for methicillin-resistant Staphylococcus aureus infection in a mouse skin abrasion model." Lasers in surgery and medicine 42(1): 38.

González-Zorn, B., J. Senna, et al. (2005). "Bacterial and host factors implicated in nasal carriage of methicillin-resistant Staphylococcus aureus in mice." Infection and immunity 73(3): 1847.

Yang, L., J. Johansson, et al. (2010). "Surfactant Protein B Propeptide Contains a Saposin-Like Protein Domain with Antimicrobial Activity at Low pH." The Journal of Immunology 184(2): 975.

Bucki, R., K. Leszczynska, et al. (2010). "Combined antibacterial and anti-inflammatory activity in a cationic disubstituted dexamethasone spermine conjugate (D2S)." Antimicrobial Agents and Chemotherapy.

Del Pozo, J., M. Rouse, et al. (2009). "Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms." Antimicrobial agents and chemotherapy 53(1): 35.

Dai, T., G. Tegos, et al. (2009). "Chitosan acetate bandage as a topical antimicrobial dressing for infected burns." Antimicrobial Agents and Chemotherapy 53(2): 393.

Sadikot, R. and T. Blackwell (2008). "Bioluminescence: imaging modality for in vitro and in vivo gene expression." Methods Mol Biol 477: 383-394.

Kadurugamuwa, J. and K. Francis (2008). "Bioluminescent imaging of bacterial biofilm infections in vivo." METHODS IN MOLECULAR BIOLOGY-CLIFTON THEN TOTOWA- 431: 225.

Aguinaldo S. Garcez, Martha S. Ribeiro et. al. (2007). "Antimicrobial photodynamic therapy combined with conventional endodontic treatment to eliminate root canal biofilm infection." Lasers in Surgery and Medicine 39: 59-66.

Garcez, A., S. Nunez, et al. (2007). "Photonic real-time monitoring of bacterial reduction in root canals by genetically engineered bacteria after chemomechanical endodontic therapy." Brazilian Dental Journal 18: 202-207.

Apidianakis, Y., M. Mindrinos, et al. (2007). "Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma." PLoS One 2(12).

Burkatovskaya, M., G. Tegos, et al. (2006). "Use of chitosan bandage to prevent fatal infections developing from highly contaminated wounds in mice." Biomaterials 27(22): 4157-4164.

Kadurugamuwa, J., K. Modi, et al. (2005). "Noninvasive biophotonic imaging for monitoring of catheter-associated urinary tract infections and therapy in mice." Infection and immunity 73(7): 3878.

Sadikot, R., H. Zeng, et al. (2004). "p47phox deficiency impairs NF-{kappa} B activation and host defense in Pseudomonas pneumonia." The Journal of Immunology 172(3): 1801.

Kadurugamuwa, J., L. Sin, et al. (2003). "Direct continuous method for monitoring biofilm infection in a mouse model." Infection and immunity 71(2): 882.

BitMansour, A., S. Burns, et al. (2002). "Myeloid progenitors protect against invasive aspergillosis and Pseudomonas aeruginosa infection following hematopoietic stem cell transplantation." Blood 100(13): 4660.

Del Pozo, J., M. Rouse, et al. (2009). "Effect of electrical current on the activities of antimicrobial agents against Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis biofilms." Antimicrobial agents and chemotherapy 53(1): 35.

Rusckowski, M., L. Chen, et al. (2008). Selecting among bacteria specific bacteriophages by optical imaging. Society of Nuclear Medicine Annual Meeting Abstracts, Soc Nuclear Med.

Mook-Kanamori, B., M. Rouse, et al. (2009). "Daptomycin in experimental murine pneumococcal meningitis." BMC Infectious Diseases 9(1): 50.

Kirby, A., L. Beattie, et al. (2009). "SIGNR1-Negative Red Pulp Macrophages Protect against Acute Streptococcal Sepsis after Leishmania donovani-Induced Loss of Marginal Zone Macrophages." American Journal of Pathology 175(3): 1107.

Wang, J., R. Barke, et al. (2008). "Morphine Induces Defects in Early Response of Alveolar Macrophages to Streptococcus pneumoniae by Modulating TLR9-NF-{kappa} B Signaling." The Journal of Immunology 180(5): 3594.

Ogunniyi, A., J. Paton, et al. (2008). "c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection." Vaccine 26(36): 4676-4685.

Srivastava, A., P. Henneke, et al. (2005). "The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease." Infection and immunity 73(10): 6479.

Kadurugamuwa JL, M. K., Yu J, Francis KP, Orihuela C, Tuomanen E, Purchio AF, Contag PR. (2005). "Noninvasive monitoring of pneumococcal meningitis and evaluation of treatment efficacy in an experimental mouse model." Molecular Imaging 4(2): 137-142.

Kadurugamuwa, J., K. Modi, et al. (2005). "Reduction of astrogliosis by early treatment of pneumococcal meningitis measured by simultaneous imaging, in vivo, of the pathogen and host response." Infection and immunity 73(12): 7836.

Orihuela, C., G. Gao, et al. (2003). "Organ-specific models of Streptococcus pneumoniae disease." Scandinavian journal of infectious diseases 35(9): 647-652.

Malley, R., P. Henneke, et al. (2003). "Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection." Proceedings of the National Academy of Sciences of the United States of America 100(4): 1966.

Echchannaoui, H., K. Frei, et al. (2002). "Toll like receptor 2–deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation." The Journal of infectious diseases 186: 798-806.

Francis, K., J. Yu, et al. (2001). "Visualizing pneumococcal infections in the lungs of live mice using bioluminescent Streptococcus pneumoniae transformed with a novel gram-positive lux transposon." Infection and immunity 69(5): 3350.

Orihuela, C., J. Radin, et al. (2004). "Microarray analysis of pneumococcal gene expression during invasive disease." Infection and immunity 72(10): 5582.

Orihuela, C., G. Gao, et al. (2003). "Organ-specific models of Streptococcus pneumoniae disease." Scandinavian journal of infectious diseases 35(9): 647-652.

Francis, K., J. Yu, et al. (2001). "Visualizing pneumococcal infections in the lungs of live mice using bioluminescent Streptococcus pneumoniae transformed with a novel gram-positive lux transposon." Infection and immunity 69(5): 3350.

Orihuela, C., J. Radin, et al. (2004). "Microarray analysis of pneumococcal gene expression during invasive disease." Infection and immunity 72(10): 5582.

Orihuela, C., G. Gao, et al. (2003). "Organ-specific models of Streptococcus pneumoniae disease." Scandinavian journal of infectious diseases 35(9): 647-652.

Georgel, P., K. Crozat, et al. (2005). "A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria." Infection and immunity 73(8): 4512.

Park, H. and P. Cleary (2005). "Active and passive intranasal immunizations with streptococcal surface protein C5a peptidase prevent infection of murine nasal mucosa-associated lymphoid tissue, a functional homologue of human tonsils." Infection and immunity 73(12): 7878.

Chung, H., M. Cartwright, et al. (2008). "Dynamical system analysis of Staphylococcus epidermidis bloodstream infection." Shock 30(5): 518.

Rusckowski, M., L. Chen, et al. (2008). Selecting among bacteria specific bacteriophages by optical imaging. Society of Nuclear Medicine Annual Meeting Abstracts, Soc Nuclear Med.

Nguyen, V., H. Kim, et al. (2010). "Genetically Engineered Salmonella typhimurium as an Imageable Therapeutic Probe for Cancer." Cancer Research 70(1): 18.

Curbelo, J., K. Moulton, et al. (2010). "Photonic characteristics and ex vivo imaging of Escherichia coli-Xen14 within the bovine reproductive tract." Theriogenology 73(1): 48-55.

Nijnik, A., L. Madera, et al. (2010). "Synthetic Cationic Peptide IDR-1002 Provides Protection against Bacterial Infections through Chemokine Induction and Enhanced Leukocyte Recruitment." The Journal of Immunology 184(5): 2539.

Menezes, G., W. Lee, et al. (2009). "Selective Down-Regulation of Neutrophil Mac-1 in Endotoxemic Hepatic Microcirculation via IL-10." The Journal of Immunology 183(11): 7557.

Sharma, P., E. Engels, et al. (2009). "Spatiotemporal progression of localized bacterial peritonitis before and after open abdomen lavage monitored by in vivo bioluminescent imaging." Surgery.

Georgel, P., K. Crozat, et al. (2005). "A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria." Infection and immunity 73(8): 4512.

Isaksson, E., M. Aili, et al. (2009). "The Membrane Localization Domain Is Required for Intracellular Localization and Autoregulation of YopE in Yersinia pseudotuberculosis." Infection and immunity 77(11): 4740.

Hudson, K. and A. Bouton (2006). "Yersinia pseudotuberculosis adhesins regulate tissue-specific colonization and immune cell localization in a mouse model of systemic infection." Infection and immunity.

Brandl, K., G. Plitas, et al. (2007). "MyD88-mediated signals induce the bactericidal lectin RegIII {gamma} and protect mice against intestinal Listeria monocytogenes infection." Journal of Experimental Medicine 204(8): 1891.

Hardy, J., K. Francis, et al. (2004). "Extracellular replication of Listeria monocytogenes in the murine gall bladder." Science 303(5659): 851.

Dai, T., G. Tegos, et al. (2009). "Chitosan acetate bandage as a topical antimicrobial dressing for infected burns." Antimicrobial Agents and Chemotherapy 53(2): 393.

Kadurugamuwa, J. and K. Francis (2008). "Bioluminescent imaging of bacterial biofilm infections in vivo." METHODS IN MOLECULAR BIOLOGY-CLIFTON THEN TOTOWA- 431: 225.

Aguinaldo S. Garcez, Martha S. Ribeiro et. al. (2007). "Antimicrobial photodynamic therapy combined with conventional endodontic treatment to eliminate root canal biofilm infection." Lasers in Surgery and Medicine 39: 59-66.

Burkatovskaya, M., G. Tegos, et al. (2006). "Use of chitosan bandage to prevent fatal infections developing from highly contaminated wounds in mice." Biomaterials 27(22): 4157-4164.

Kadurugamuwa, J., K. Modi, et al. (2005). "Noninvasive biophotonic imaging for monitoring of catheter-associated urinary tract infections and therapy in mice." Infection and immunity 73(7): 3878.