Influenza A virus PB1-F2: a small protein with a big punch

Cell Host Microbe

G. M. Conenello, P. Palese

Virulence factors, such as the recently discovered PB1-F2, contribute to the pathogenesis and comorbidity of influenza A virus. In this issue of Cell Host & Microbe, McAuley et al. characterize the role of PB1-F2, including in the pandemic 1918 virus, in causing increased lung pathology and fatal pneumococcus infection in mice. This work sheds light on the mechanisms of pathogenicity during influenza A virus infections.

2007
Cell Host Microbe
Volume: 2. Issue: 4. Pages: 207-9.

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• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18005736