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Technologies

Metabolic Disease Models


Retn-luc Expression in Male and Female Mice
Two regions of interest (ROIs) were examined on the ventral and dorsal sides of the animals.



Rip-luc Expression in Male and Female Mice
Example of RIP-luc transgene expression in the light-producing transgenic mice demonstrating pancreas-specific transgene expression.



Rip-luc Streptozotocin Treatment Decreased Luciferase Expression
Luciferase Signal


Rip-luc Islet Transplantation Recipent Mice Treated with STZ Prior to Transplantation

Credits: Dixon Kaufman, Northwestern University


  • Islets (300) were transplanted via portal vein infusion.
  • Transplanted islets functioned to rescue the STZ-induced diabetes.
  • Transplanted islets survived in hosts for >30 day islets.